Amazing Spider-Man #258
Peter Parker loses the Venom Symbiote and had to settle for a Fantastic Four suit and a brown paper bag. Hence, the birth of the Amazing Bag-Man.
I bet Spiderman left New York City for a day trip and when he came back, he saw the catastrophic aftermath of The Avengers and he was like
“I WAS GONE FOR ONE DAY. ONE DAY.”
“We love our superheroes because they refuse to give up on us. We can analyze them out of existence, kill them, ban them, mock them, and still they return, patiently reminding us of who we are and what we wish we could be.” - Grant Morrison